HEMOPOIETIC SPLEEN COLONY STUDIES

Hemopoietic Spleen Colony Studies

The effects of phytohemagglutinin (PHA) were studied in irradiated mice to see if a definite myeloproliferative effect could be demonstrated in vivo. The data obtained suggested the following conclusions. PHA treatment of the bone marrow donor only, causes a consistent but slight reduction in transplantable spleen colony-forming unit (CFU) content of the bone marrow 24 hr after the last PHA inj...

Hemopoietic Colony Studies

In heavily irradiated mice, bone marrow regeneration of either endogenous or exogenous origin was shown to occur in discrete foci comparable to the more intensively studied spleen colonies. The number of endogenous bone marrow colonies was inversely related to dose of whole body X-irradiation. Endogenous marrow colonies were found after higher doses of irradiation than were endogenous spleen co...

Hemopoieitc Spleen Colony Studies

The polycythemic repression of erythropoiesis and the restoration of erythropoiesis by specific stimulation were studied in the spleen colony system in irradiated mice. 1. A 5 day period of erythropoietin stimulation (exogenous erythropoietin) or repression (polycythemia) of the bone marrow donor only, does not significantly alter the number or type of colonies formed by the transplanted marrow...

Studies on the regulation of hemopoietic spleen colonies.

Observations on the settling and recoverability of transplanted hemopoietic colony-forming units in the mouse spleen.

A series of experiments was designed determining the seeding and ultimate to study the effect of spleen size on retention of CFU in the spleen of a the seeding and retention of spleen recipient mouse is the size of the colony-forming units (CFU) after inspleen. It is concluded that the most jection into irradiated mice. The cellureasonable value of the fraction’ of larity of the spleens of reci...